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Electron micrograph of Hendra virus.

Electron micrograph of Hendra virus.

Hendra virus

In 1994, a deadly new virus threatened to stop Australia's premier horse race – the Melbourne Cup. This virus is now known as Hendra virus.

  • 13 May 2011 | Updated 14 October 2011

Background

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In September 1994, a prominent Queensland horse trainer Mr Vic Rail, his stablehand, and most of his horses fell ill to a sudden and mysterious illness.

Within several days, the trainer and 14 horses were dead.

As the Queensland Department of Primary Industries (QDPI) collected specimens from affected race horses and submitted them for testing at CSIRO's Australian Animal Health Laboratory (AAHL) in Geelong, Victoria, newspapers ran with headlines like 'Death virus cancels races, threatens Cup'.

AAHL's diagnostic team isolated and identified what proved to be a new virus that had not been reported anywhere else in the world.

Researchers initially named it equine morbillivirus, however, further genetic analysis showed that the most appropriate classification of the virus was as a new genus within the Paramyxoviridae family.

CSIRO's Australian Animal Health Laboratory has been actively involved in each recorded Hendra virus incident since it first emerged in 1994.

The name Hendra is now used, after the name of the Brisbane suburb in which the outbreak occurred.

The strength of AAHL's capabilities was clearly demonstrated by the manner in which the infectious agent was isolated, the disease reproduced in horses and the virus eventually identified using electron microscopy and gene sequence analysis.

With the cause of the disease outbreak known, AAHL researchers developed diagnostic tests.

QDPI, Queensland Health and AAHL tested more than 2 500 horse samples and 150 human samples, not finding any new cases.

Further cases (current February 2011)

In the last 17 years, seven people have been confirmed to have been infected with Hendra virus, four of whom have died as a result of the disease.

In addition to the initial case in 1994, a farmer from Mackay died in 1995 and two Queensland vets passed away in separate incidents in 2008 and 2009.

There have also been 14 clusters of Hendra virus infection recorded in horses since the virus was first identified.

As a National Facility, AAHL provides diagnosis of emergency animal diseases, which includes:

  • index case confirmation 
  • national emergency response capability
  • use of accredited and validated tests.

The facility has been actively involved in each recorded Hendra virus incident, working alongside Queensland Primary Industries and Fisheries and Queensland Health.

References

1. McEacherna JA, Bingham J, Crameri G, Green DJ, Hancock TJ, Middleton D, Feng Y-R, Broder CC, Wang L-F, Bossart KN. 2008. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats [external link]. Vaccine. 26(31): 3842-52.

2. Bossart KN, Zhu Z, Middleton D, Klippel J, Crameri G, Bingham J, McEachern JA, Green D, Hancock TJ, Chan Y-P, Hickey AC, Dimitrov DS, Wang L-F, Broder CC. 2009. A neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection. PLoS Pathog 5(10): e1000642. doi:10.1371/journal.ppat.1000642.

Fast facts

  • In 1994, CSIRO and Queensland researchers discovered a completely new virus now called Hendra virus
  • Scientists believe fruit bats are the natural 'hosts' of Hendra, meaning the virus is carried by bats but has little effect on them
  • Hendra virus is not highly contagious but if transmitted to horses and humans can be lethal
  • CSIRO has shown that a prototype vaccine can protect horses against Hendra virus

Contact Information

CSIRO Enquiries

Phone: 1300 363 400

Alt Phone: 61 3 9545 2176

Email: Enquiries@csiro.au

Ms Emma Wilkins

Communications Advisor

CSIRO Livestock Industries

Phone: 61 3 5227 5123

Alt Phone: 61 4 0903 1658

Email: Emma.Wilkins@csiro.au

Location

Australian Animal Health Laboratory

5 Portarlington Rd

East Geelong VIC 3219

Australia

Explore CSIRO

Community

CSIRO aims to establish and build relationships with members of the community. We welcome people of all ages to come and explore our facilities, holiday programs and public events.

Contact

Phone:

1300 363 400

Email:

enquiries@csiro.au

More contact options

About CSIRO

CSIRO, the Commonwealth Scientific and Industrial Research Organisation, is Australia's national science agency and one of the largest and most diverse research agencies in the world.

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