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CSIRO, the Commonwealth Scientific and Industrial Research Organisation, is Australia's national science agency and one of the largest and most diverse research agencies in the world.

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Image of cells identified and measured using image analysis technology

Image analysis technologies can automatically identify individual cells and measure them

Biotech imaging: imaging for research, diagnostics and drug development

CSIRO develops leading edge methods and software to extract quantitative information from digital images.

  • 27 July 2011 | Updated 14 October 2011

Automating imaging applications

Digital images contain a wealth of information.

The medical and biotech industries produce massive amounts of image data using technologies such as microscopy, microplate readers, and microarray scanners for purposes like:

  • disease diagnostics
  • drug discovery
  • quality control.

CSIRO’s image analysis research supports the automation of such applications, while boosting throughput, reliability and reproducibility.

Key science issues

One of the key issues addressed at CSIRO is to develop computer vision tools that, like the human eye, can recognise and discriminate between objects but are also able to make detailed, accurate measurements much better and faster than people can.

The CSIRO Biotech Imaging team is led by Dr Pascal Vallotton. The team’s software has been built into commercially available instruments.

How CSIRO is addressing these issues

CSIRO’s Biotech Imaging team is applying a growing portfolio of image analysis technologies to problems like:

  • measuring and classifying the shapes of nerve cells exposed to drug treatments
  • reliably diagnosing melanoma, the most dangerous form of skin cancer
  • detecting contamination in tablets
  • determining the extent of crack damage in roads and other surfaces.

We are currently developing cellular screening tools for location proteomics, neurobiology and microbiology.

As part of CSIRO's Computational and Simulation Sciences initiative, we are also exploring applications of graphics processing units (GPUs) to speed up image analysis tasks.

Commercial achievements

CSIRO image analysis software has been built into commercially-available instruments such as:

CSIRO's HCA-Vision measures and classifies the shapes of nerve cells.

CSIRO’s HCA-Vision helps researchers find more effective, safer pharmaceuticals and better understand the mechanisms of disease. HCA-Vision is an automated image analysis software package that rapidly and reproducibly measures functional features of neuronal cells in two-dimensional (2D) images.

Image of brown skin lesion with boundaries automatically detected, shown by a yellow outline and hair shown as green lines.

Australian medical instrumentation company Polartechnics came to CSIRO to develop image analysis software for a device that supports diagnosis of melanoma, skin cancer’s deadliest form.
CSIRO image analysis technology is built into SolarScan®, a device that helps doctors detect melanoma earlier.

Photo: SPOT, a software package for analysing microarray images.

CSIRO has a track record in developing innovative solutions to practical problems. Our Spot software, a microarray spot detection and characterisation package, helps researchers get better gene expression information. Trial an evaluation copy of Spot 3.0.

We also have contributed the image analysis in projects concerning:

Photograph of two workers in a white truck driving along road

CSIRO’s automated road sensing system, RoadCrack, is able to find cracks in road paving down to a width of one millimetre at high speeds, reducing the cost and increasing the accuracy of road crack detection.  

image of mouse lung showing composition changes in different parts of the tissue

Checking the contents of tablets, finding new ore bodies to mine, identifying tumours – these are just some of the applications of hyperspectral imaging. This technology has been the focus of CSIRO research which helps determine the composition of different materials and how composition varies throughout the material.

A cell image showing the branching structure of neurites, captured using three fluorescence channels.

CSIRO helped Axon instruments develop image analysis software for their ImageXpress™ cellular screening system. ImageXpress™ helps researchers discover safer drugs more quickly.

Learn more about our work in Quantitative biosciences research overview.

  • SolarScan™ is a trade mark of  Polartechnics
  • ImageXpress™ is a trade mark of Axon Instruments
  • RoadCrack™ is a trade mark of CSIRO Australia.

Fast facts

  • Image analysis software allows computers to do many tasks normally carried out by eye
  • CSIRO Biotech Imaging's focus is health and biotechnology
  • Many years’ of CSIRO image analysis research has led to unique skills and extensive software libraries
  • CSIRO Biotech Imaging has a successful track record of working with industry
  • The team has won numerous awards and is internationally respected in its field

Contact Information

Dr Pascal Vallotton (PhD)

Stream Leader

Phone: 61 2 9325 3208

Alt Phone: 61 4 0080 1245

Email: Pascal.Vallotton@csiro.au

Ms Carrie Bengston

Communication Manager

Phone: 61 2 9325 3224

Alt Phone: 61 2 9325 3000

Email: Carrie.Bengston@csiro.au

Location

CSIRO Mathematics, Informatics and Statistics - North Ryde

Building E6B Macquarie University Campus

North Ryde NSW 2113

Australia

Explore CSIRO

Community

CSIRO aims to establish and build relationships with members of the community. We welcome people of all ages to come and explore our facilities, holiday programs and public events.

Contact

Phone:

1300 363 400

Email:

enquiries@csiro.au

More contact options

About CSIRO

CSIRO, the Commonwealth Scientific and Industrial Research Organisation, is Australia's national science agency and one of the largest and most diverse research agencies in the world.

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