Preventative Health Presentations for October 2005 to January 2006

Dr Richard Head, Flagship Director

A listing of some of the recent presentations of Flagship work:

Nutrigenomics

“Genome health – A Nutrigenomics Approach to Setting Dietary Recommendations”, paper presentation by Dr Michael Fenech, Principal Research Scientist and Project Leader, Nutrigenomics and Genome Health, CSIRO Human Nutrition, to the International Life Sciences Institute (ILSI) Southeast Asia Region First International Conference on Nutrigenomics, Singapore, December 9, 2005.

“Optimising Health through Nutrigenomics”, paper presentation by Professor Richard Head, Director, CSIRO Preventative Health National Research Flagship, to the International Life Sciences Institute (ILSI) Southeast Asia Region First International Conference on Nutrigenomics, Singapore, December 9, 2005.

“Dietary Factors and Genome Stability – the Link” , paper presentation by Preventative Health Flagship Fellow and Director of Development for the Flinders Centre for Innovation in Cancer Care, Prevention and Research, Adelaide Professor Graeme Young to the International Life Sciences Institute (ILSI) Southeast Asia Region First International Conference on Nutrigenomics, Singapore, December 8, 2005.

“Improving Nutritional Quality of Dairy and Meat Products", paper presentation  by Dr Shaun Coffey, Chief, CSIRO Livestock Industries, to the International Life Sciences Institute (ILSI) Southeast Asia Region First International Conference on Nutrigenomics, Singapore, December 9, 2005.

“Genetics, Epigenetics and Nutrition,” paper presentation by Dr Lynne Cobiac, Research Leader, Protective Foods, Preventative Health Flagship, pre-conference seminar, to the International Life Sciences Institute (ILSI) Southeast Asia Region First International Conference on Nutrigenomics, Singapore, December 6, 2005.

“Structure-Activity Relationship of Butyrate Analogues in HT-29 Human Colorectal Cancer Cells”, poster presentation by Cheng Cheng Ooi, Richard Head, Leah Cosgrove and Desmond Williams to 2005 Joint Meeting of APSA-ASCEPT, Melbourne, December 4-7, 2005.

“Effect of pH and Butyrate on Proliferation and Apoptosis of HT-29 Human Colorectal Cancer Cells”, poster presentation by Cheng Cheng Ooi, Richard Head, Leah Cosgrove and Desmond Williams to the International Life Sciences Institute (ILSI) Southeast Asia Region First International Conference on Nutrigenomics, Singapore, December 7-9, 2005.

Diagnostics from molecular biology of colorectal cancer

“Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain”,  Denley A, Brierley GV, Carroll JM, Lindenberg A, Booker GW, Cosgrove LJ, Wallace JC, Forbes BE, Roberts CT Jr. Endocrinology. Published Feb 2006;147(2):1029-36.

“The Biological Role of Insulin-like Growth Factors Signalling via IR-A and IR-A/IGF1R Hybrid Receptors in Cell Survival, Migration, and Invasion.” Gemma V Brierley, Briony E Forbes, Lance Macaulay, Ken Siddle, John C Wallace, and Leah J Cosgrove. Poster Presentation, presenting author: Gemma V Brierley at the “The Role of the IGF System in Cancer” conference in Taormina, Sicily, Italy in November 10 – 12, 2005

“The potential role of GPCR43  in butyrate-induced inhibition of proliferation and induction of apoptosis in colorectal cancer cells”, Michelle H Zucker1,2*, Leah J Cosgrove1,2, John C Wallace3, Richard J Head2. Poster presentation: presenting author; Michelle Zucker at ILSI’s First International Conference on Nutrigenomics – Opportunities in Asia, Raffles, Singapore, December 7 – 9, 2005

“Identification of a putative butyrate receptor (GPCR43) in HT-29 colorectal cancer cells”, Michelle H Zucker*, Leah J Cosgrove, John C Wallace, Richard J Head. Poster presentation: Presenting author Michelle Zucker at Combio 2005 Adelaide Convention Centre, Adelaide, Australia. 25 - 29 September, 2005 

“Inta- and inter- individual variation in circulating IGF-I, IGF-II, IGF-BP3 and insulin”, Caroline Kerr, Damien Belobrajdic, Ilka Priebe, Briony Forbes, Leah Cosgrove and Ian Saunders. AACR conference, Baltimore, USA, November, 2005

“Assessing the Biological Role of the A Isoform of the Insulin Receptor in Colorectal Cancer”, oral presentation given by Gemma Brierley to the Institute of Molecular Medicine, University of Oxford, Oxford, UK on 14th December 2005 and to the Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK on 15th December 2005

“Colon cancer; animal dietary studies to human biomarkers,” Dr Damien Belobrajdic, oral presentation to CMHT Parkville – divisional seminar, August 9 2005 

“The education of a young scientist under the microscope,” keynote address by Dr Damien Belobrajdic, Conference of the Science Educators of the ACT, 1-2 December 2005 

Novel scaffolds for peptide display:

“Ribosome display for improved biotherapeutic molecules”, Rothe A, Hosse RJ and Power BE (2006). Exp. Opin. Biol. Ther  6(2): 177-87.

“A new generation of protein display scaffolds for molecular recognition”, Hosse RJ, Rothe A and Power BE (2006). Protein Science 15(1): 14-27

“A Novel human scaffold for the presentation of ligand binding surfaces”, B.E. Power, R. Surjadi, L. Pearce, R. Attwood, U.V. Krishnan, R.J. Hosse, J.N. Varghese and P.J. Hudson (2005). Oral presentation to the Second China International Symposium on Antibody Engineering and Antibody-based Therapeutics, Beijing, China.

Health Data Integration

“Linking Health Data While Preserving Privacy”, poster presented by Anthony Maeder at NCRI Cancer Conference, Birmingham UK, 2-5 October 2005

“Data comparison using encrypted data and data clusters”, patent filed by Chaoyi Pang and Lifang Gu.

“HDI: Integrating Health Data and Tools”, paper published by D Hansen,  C Pang, A Maeder in Journal of Soft Computing, Special Issue for the International Conference on Machine Learning and Cybernetics (ICMLC 2005)

“Health Data Integration: Current Status”, oral presentation by David Hansen at CSIRO ICT Conference 2005, Sydney, 8-9 November 2005

Statistics and Bioinformatics 

“Robust Autofocusing for Automated Microscopy Imaging of Fluorescently Labelled Bacteria”, Hilsenstein, V, In Proceedings of the Digital Image Computing: Techniques and Applications (DICTA 2005), pages 95--101, Cairns, Australia, 6-8 December 2005, IEEE Computer Society Press.

Genetic analysis of colorectal cancer risk

“PCC: an algorithm for accurate estimation of SNP allele frequencies in small equimolar pools of DNA using data from high density microarrays”, 1) Jesper Brohede 2) Rob Dunne 3) James McKay 4) Garry Hannan, published in Nucleic Acids Research, 33(17):e142

“Genome-wide, SNP genotyping with AFFYMETRIX microarrays to detect novel cancer gene”, Brohede J^1,2, McKay JD^3,4, FitzGerald LM³, Stankovich J⁵, Dickinson JL³ & Hannan GN^1,2*

¹CSIRO Preventative Health National Research Flagship, Sydney, Australia; ²CSIRO MolecularScience, Sydney, Australia;  ³Menzies Research Institute, University of Tasmania, Hobart, Australia; ⁵International Agency for Research on Cancer, Lyon, France; ⁵Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

*Selected oral presentation. HUGO Workshop: Mutation Detections 2005, antorini, Greece, . May 31-June 4, 2005.

“PPC: an algorithm for accurate estimation of SNP allele frequencies in small equimolar pools of DNA using data from high density microarrays”, Jesper Brohede^1,2*, Rob Dunne^1,3 James McKay^4,5, Garry Hannan^1,2,

¹CSIRO Preventative Health National Research Flagship, Sydney, Australia; ²CSIRO Molecular and Health Technologies, Sydney, Australia; ³CSIRO Mathematical and Information Sciences, Sydney, Australia; ⁴Menzies Research Institute, University of Tasmania, Hobart, Australia; ⁵International Agency for Research on Cancer, Lyon, France.

*Selected oral presentation. GeneMappers 2005, Mount Buller, Vic. November 23-25 2005.

“IBD-based run tests in genome scans for colorectal cancer susceptibility genes”, Ian W Saunders^1,2*, Jesper Brohede^1,3, Garry Hannan^1,3, John Hopper⁴, Mark Jenkins⁴ & Melissa Southey^5,6

¹CSIRO P-Health Flagship; ²CSIRO Mathematical & Information Sciences; ³CSIRO Molecular & Health Technologies; ⁴Centre for Genetic Epidemiology, University of Melbourne; ⁵Department of Pathology, University of Melbourne; ⁶International Agency for Research on Cancer, Lyon, France.

*Selected oral presentation. GeneMappers 2005, Mount Buller, Vic. November 23-25 2005.

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Preventative Health Presentations for October 2005 to January 2006

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The Preventative Health Flagship is a CSIRO initiative and part of the National Research Flagships program that aims to deliver scientific solutions to advance Australia's most important national objectives. One of the largest scientific initiatives ever mounted in Australia, it aligns closely with the Federal Government's National Research Priorities. The initiative brings together our national research resources to deliver breakthroughs in fields ranging from healthcare to light metals and the environment.

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