In this issue:
Merry Christmas from the RAFT team
From all of our CSIRO RAFT Team to all of you in the RAFT community we wish you a very safe and happy Christmas and New Year!
2011 seems to have flown by but not without some significant highlights worth mentioning here:
- A new commercial product made using RAFT has been launched by Lubrizol
- We have signed a number of new licences in exclusive and non exclusive industrial areas
- Ezio Rizzardo has had an amazing year being named in the top 100 chemists in this International Year of Chemistry and then recently with colleague David Solomon receiving the Prime Minister's Science Prize for work in polymer innovation particularly in Ezio's case the development of the RAFT Technology. Prizes for Science are the nation's pre-eminent awards for excellence in science.
- Our intrepid RAFT team travelled far and wide to a number of scientific, industrial and financial conferences to promote the opportunities for RAFT – see where we are heading next to see if there is an opportunity for us to meet up
- We have had a number of key papers published. Most recently our paper on RAFT-Derived Polymer-Drug Conjugates: Poly(hydroxypropyl methacrylamide)-SN-38 Conjugates" has been published online by ChemMedChem (see story below).
We are looking forward to another exciting year in 2012 and hope to see as many of you as possible on our travels!
CSIRO's RAFT Team
PACIA networking event in Melbourne
CSIRO hosted Australia’s Plastics and Chemicals Peak body PACIA’s final network meeting of the year. This was a great opportunity for us to showcase our RAFT technology and also the work in flow chemistry that we have been doing in the innovative chemical manufacturing area to this industry. Both technologies offer significant benefits to industry and were very well received by the audience.
For more information, contact Dr Greg Simpson.
Dr John Tsanaktsidis (L) and Dr Greg Simpson (R) at the recent PACIA network meeting.
Dr Ezio Rizzardo (L) and Dr Greg Simpson (R) enjoying the refreshments at the recent PACIA network meeting.
Important new paper: RAFT-derived polymer-drug conjugates
Recently published in the latest edition of ChemMedChem, this article explains how RAFT was employed to grow a polymer from an existing known drug molecule (SN-38) – in this case an anti-cancer drug – and to observe the polymer's effect on the physical properties and activity of the drug in its modified form. Observations included that the activity of the conjugate was largely retained, plus the previously sparingly soluble SN-38 became water soluble after the polymer was attached.
The article is available online via the Wiley website.
For more information, contact Dr John Tsanaktsidis.
The article abstract:
Williams, C. C., Thang, S. H., Hantke, T., Vogel, U., Seeberger, P. H., Tsanaktsidis, J. and Lepenies, B. (2011), RAFT-Derived Polymer–Drug Conjugates: Poly(hydroxypropyl methacrylamide) (HPMA)–7-Ethyl-10-hydroxycamptothecin (SN-38) Conjugates. ChemMedChem. doi: 10.1002/cmdc.201100456
A series of well-defined polymer–drug conjugates
were prepared in order to modify the physical properties
of a known cytotoxic drug, 7-ethyl-10-hydroxycamptothecin
(SN-38), the active metabolite of irinotecan (CPT-11). Reversible
addition–fragmentation chain transfer (RAFT) polymerisation
was used to covalently and site-specifically append a defined
N-(2-hydroxypropyl)methacrylamide (HPMA) polymer to SN-38
using a graft-from process. These poly-HPMA–SN-38 conjugates
displayed excellent aqueous solubility and stability,
whilst retaining the cytotoxic activity of the parent SN-38. In
vitro co-culture assays containing both cancer and noncancer
cell lines demonstrated the specificity of RAFT-derived poly-
HPMA–SN-38 conjugates for cancerous cells. The concept of
post-optimisation modification of small-molecule drugs
through a graft-from polymer conjugation method is introduced.
New RAFT animation
CSIRO has recently added a new interactive animation to the RAFT website which answers that old chestnut "What is RAFT and why is it different?".
You can find it on the RAFT home page: www.csiro.au/products/RAFT.
The animation is iPad compatible, so you can play it anywhere!
Recent conference news
SCC Technology Showcase
Peggy Stasinos and John Chiefari attended the Society of Cosmetics Chemists 2011 Annual Scientific Meeting and Technology Showcase in New York on 8-9 December. Dr Chiefari presented a poster entitled "RAFT: making better polymers for improved cosmetics". You can download the content of the poster as a PDF here (1.5MB).
Green Chemistry Innovations Conference
CSIRO took part in the 3rd Asia-Oceania Conference on Green and Sustainable Chemistry (AOC-3). The theme of the conference 'Green Chemistry Innovations' was chosen to reflect the unique nature of the Asia and Oceania Green and Sustainable Chemistry Network and to reinforce the strong commitment by CSIRO to green chemistry and engineering as the key for a more sustainable future.
The event, held at the Melbourne Convention and Exhibition Centre, brought together researchers from all over the world, along with industry leaders, educators and government representatives. In all over 300 delegates attended the conference.
CSIRO was a key sponsor of the conference and one of our RAFT team Dr Greg Simpson spoke about Green Materials and Public Policy.
CSIRO's stand at the recent Green Chemistry Innovations conference.
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The CSIRO RAFT team will be travelling widely to attend a number of local and international conferences and events in 2012. These are great opportunities for us to meet and talk with you about how RAFT can provide solutions to your material science challenges. Why not get in touch if you're at any of the same events or nearby and we can meet up?
Drug Delivery Formulation January 17-18, Berlin, Germany
Drug Delivery Partnerships, January 25-27, Las Vegas, USA
39th Annual Waterborne Symposium, February 13-17, New Orleans, USA
Informex, February 12-15, New Orleans, USA
33rd Australasian Polymer Symposium, February 12-15, Hobart, Australia
SPIE Advanced Lithography, February 12-16, San Jose, USA
BioNetwork East 2012, March 5 -7, Miami, Florida
WBT Innovation Marketplace, 22-23 March, Texas USA
ACS Spring Meeting, 25-29 March, San Diego, USA
Keddie, D. J.; Guerrero-Sanchez, C.; Moad, G.; Rizzardo, E.; Thang, S. H., Switchable Reversible Addition–Fragmentation Chain Transfer (RAFT) Polymerization in Aqueous Solution, N,N-Dimethylacrylamide. Macromolecules 2011, 44, 6738-45.
Houshyar, S.; Keddie, D.; Moad, G.; Mulder, R.; Saubern, S.; Tsanaktsidis, J., Synthesis of Macro-RAFT Agents by Sequential Insertion of Single Monomer Units. Polym. Chem. 2012, accepted for publication.
Moad, G.; Chen, M.; Haeussler, M.; Houshyar, S.; Keddie, D.J.; Rizzardo, E.; Thang, S.H.; Tsanaktsidis, J., Some Recent Developments in RAFT Polymerization. Advanced Polymeric Materials 2011. 1st Korean-Australian International Joint Symposium, Gumi, Korea, 2011, 54
Moad, G.; Bicciocchi, E.; Chen, M.; Chiefari, J.; Guerrero-Sanchez, C.; Haeussler, M.; Houshyar, S.; Keddie, D.J.; Rizzardo, E.; Thang, S.H.; Tsanaktsidis, J., End Group Transformation in RAFT Synthesized Polymers. 12th Pacific Polymer Conference, Jeju Is, Korea, 2011, Paper ISL1-09
Chiefari, J.; Guerrero-Sanchez, C.; Moad, G.; Thang, S. H.; Tsanaktsidis, J.; Gunatillake, T.; Hinton, T.; Shi, S.; Tizard, M, RAFT polymerization for delivery of bioactives. In Nanotech Conference & Expo 2011: An Interdisciplinary Integrative Forum on Nanotechnology, Biotechnology and Microtechnology, Ed. Laudon, Matthew; Romanowicz, Bart, Boston MA, United States, 2011, 3, 186-188.
Chiefari, John; Moad, Graeme; Rizzardo, Ezio; Thang, San H. RAFT: a smarter way to develop multi-functional polymers In Nanotech Conference & Expo 2011: An Interdisciplinary Integrative Forum on Nanotechnology, Biotechnology and Microtechnology, Ed. Laudon, Matthew; Romanowicz, Bart, Boston, MA, United States, 2011, 1, 632-635