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These
sneezes and snuffles may sound like the sufferers have all caught
the same bout of flu. But although the symptoms are often similar,
there are hundreds of different exotic flu viruses.
And not only that, the viruses constantly
change, making the search for a cure almost impossible. That is
until now.
The rapid rate of mutation of the flu
virus has resulted in a continuous onslaught of new strains, like
the 1918 Spanish flu which killed over 20 million people world wide,
and the virulent and deadly Hong Kong flu of the 1960's, which came
from chickens.
And each time scientists have developed
a cure, a totally different flu has emerged.
So scientists from Australia's national
science agency, Dr. Peter Coleman and Dr. Jose Varghese decided
to find out what, if anything, did flu viruses have in common.
"Although the
virus does change itself dramatically from year to year, there is
a small part of influenza virus which is absolutely the same on
every wild strain of flu that's ever been found"
What makes flues different from each
other, are two proteins which cover the virus. These proteins are
changed even more significantly if the strains have come from other
species such as pigs or poultry.
However, what the CSIRO scientists
found was a small pocket on the surface which is exactly the same
in all types of flu and has never changed in the evolution of flu
strains. So they set out find a way to plug this pocket with a designer
drug molecule. It took five years, but finally they succeeded.
The result was the world's first successful
influenza drug, called Relenza, which plugs the pocket and stops
the virus from spreading.
"Relenza is an anti viral. Everything
you've taken so far is a symptom relief medicine. Relenza also relieves
the symptoms of influenza, but it does so by attacking the virus
and not the symptoms themselves"
It has taken eight years of testing
on animals and humans to ensure that Relenza not only works, it
has absolutely no side effects. The development of Relenza is estimated
to be worth at least two billion dollars a year. And it's worth
every cent.
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