Working with us – 
Bioconjugates and Theranostics 

CSIRO offers the full spectrum of 
bioconjugation services to couple 
diverse targeting biomolecules 
(e.g., proteins, aptamers, peptides, etc.) 
to chelators (for theranostics), cytotoxic 
drugs, fluorescent tags, bespoke 
polymers, drug delivery systems, 
or surfaces (such as biosensors and 
medical implants). 

Our bioconjugation capabilities can 
be tailored to meet your unique 
research objectives based on our 
comprehensive know-how.

CSIRO offers additional in-house 
expertise in synthesis (including GMP 
manufacturing of biologics), in-depth 
characterisation, purification, assay 
development and testing, process 
development, and technology transfer.

Support for SMEs

CSIRO offers start-ups and small-to-
medium enterprises (SMEs) excellent 
opportunities to work with us through 
faciliated R&D programs. We also offer 
matched funding programs through 
‘SME Connect’. We’re here to help 
SMEs navigate the research ecosystem 
and access our world-class facilities 
and researchers. 

Did you know?

• CSIRO can perform bioconjugation 
chemistry in CSIRO’s National 
Vaccine and Therapeutics Lab 
strengthening Australia’s ability 
to deliver GMP bioconjugates for 
use in Australian clinical trials. 
• We are working with SMEs, 
Biotechnology and Pharmaceutical 
companies, and universities 
to deliver on a range of 
bioconjugation projects. 




Bespoke 
conjugation 
Linker/Drug 
(ADC) 
Chelate 
(theranostic)
Fluorescent tag 
Antigen 
Polymer 
Nanoparticle

Bioconjugation

Translation

Target 
identification

Preclinical testing

Clinical trials

Target 
identification

in vivo target 
biology and 
validation

in vitro target 
biology & 
validation

CSIRO

SMEs/Pharma

Academia/SMEs

 Lead characterisation and optimisation

Bespoke 
cell assay 
development 
& efficacy 
cytotoxicity

Purification

in vivo testing 
biodistribution 
efficacy safety 
target specificity 
animal models

Analysis & 
characterisation

Tech 
transfer

Radioisotope 
labelling 
characterization 
stability studies 

Surface 
modifications

Bespoke Chemistry 
Medicinal chemistry (linker/
API) Polymer Nanoparticle 

(Bio)molecule production

Biochemical 
assay 
development 
& testing

SPR/biophysics 
development & 
testing 

Market analysis, 
business 
development & 
commercialisation

Phase I

Phase II

Phase III

Biomolecule Production 
Antibody (+fragments) 
RNA/aptamer Peptide design


Working with us – 
CSIRO capabilities in Bioconjugate and Theranostic development and manufacture


Process 
development & 
scale-up