ON Prime Virtual is a pilot program that helps teams ensure they are working on the right problem, provides frameworks to create and test assumptions about their idea with customers and provides recommendations towards next steps. Meet the teams that make up our cohort for ON Prime Virtual.

Advanced Water Accounting

Institution: CSIRO Land & Water

Across the Murray Darling Basin (MDB) there is a fierce competition among users and water theft is not uncommon in parts of New South Wales and Victoria. Currently, authorities are using satellite imagery to monitor river flow in the northern MDB to identify when water goes missing. While these images are good for tracing surface water area, they don’t provide quantitative assessment on water volume and how much is illegally diverted. The temporal frequency of satellite imagery is also limited to only monitor daily water offtake. The Modelling Water Ecosystem team combines satellite derived water maps with advanced modelling tools and data from stream gauges, authorities to monitor these water resources more accurately. 

Food Technology

Institution: RMIT University

Food wastage due to quality and safety concerns is a societal and environmental burden. The demand for safe quality food warrants more early testing, with the food safety testing market expected to hit US $24 billion by 2025. The current methods of pathogens/spoilage micro-organisms testing are expensive, time consuming and skilled labour intensive. The Food Technology team aims to develop a rapid, reliable and cost-effective technology with the potential to be used for on-site detection of micro-organisms from paddock to plate. The technology will be of interest to diverse stakeholders both in Australia and worldwide, as detection is important to food producers/farmers, processors, food testing/diagnostics laboratories and regulators.

Lipid Paladins

Institution: RMIT University

The Lipid Paladins team is striving to develop a triggered, responsive, nanoparticle delivery technology for RNA therapeutics. These therapeutics are on the rise to defend against global health issues ranging from pandemic diseases to cancer. The biggest challenge in successful clinical translation of RNA therapeutics, despite its numerous distinctive advantages, is safe and effective delivery to the target cells and tissues. This team’s responsive platform delivery system offers a solution to transport the RNA therapeutics in the body without quick clearance and degradation. Taking advantage of pathological conditions, our system would trigger release of RNA at the site of the disease and facilitate in it crossing the cell membrane.

Robot Freeform Fabrication

Institution: CSIRO Manufacturing

Robots offer new opportunities for 3D printing. Robots can build larger objects that are 3D at a faster rate, without the geometric constraints imposed by your average 3D printer. However, integrating robots, sensors and build heads is a challenge. Conventional slicing software made for plastic 3D printers just doesn't cut it! The Robot Freeform Fabrication team is developing digital solutions for robot tool path planning and feedback control. The team has years of experience in integrating robots with metal deposition processes such as cold spray, laser and weld tools. They’ve been through the process and are hoping their software will make it easier for others.

CT Motion Correction

Institution: The University of Sydney

Motion artefacts are a common problem in clinical CT scans of the head performed for a range of investigations such as head trauma and stroke. We have developed a computer algorithm that can reprocess motion-degraded CT scans to produce images without motion artefacts for more accurate diagnosis and better treatment decisions. Its efficacy and breadth of application has been demonstrated on clinical CT data. To enable patients to benefit from this technology the CT Motion Correct team are seeking to establish a partnership with a manufacturer of clinical CT imaging systems to convert their invention into a viable commercial product.

Noble Solutions

Institution:  CSIRO Land & Water

Understanding how groundwater and other fluids move underground is crucial for sustainably managing these resources and maximising their economic benefit. Noble gases are a new tool for the understanding of natural underground fluid systems in the Australian market. They are the most ideal tracers to derive groundwater fluxes such as recharge and discharge, groundwater velocity, mixing and dispersion and connectivity between different aquifers. Noble gases also make it possible to quantify ocean fluxes, date ice cores, understand the genesis of oil and gas reservoirs and show promise in novel applications in the understanding of mineral genesis through the analysis of noble gases in fluid inclusions.


Institution: CSIRO National Collections and Marine Infrastructure

ALA-IEK Project bridges the gaps between Indigenous and western science knowledge for plants and animals by linking them in the Atlas of Living Australia, Australia’s national online biodiversity database. Indigenous people manage more than half the Australian land mass and their ecological knowledge is essential for good land management and conservation across Australia. This work also supports the health, wellbeing and empowerment of Aboriginal people by creating opportunities for reconnection to traditional language and cultural knowledge through physical, spiritual and environmental practices with plants and animals during language and knowledge workshops on Country.


Institution: The University of Sydney

ETOM is a portable and compact medical device that measures the oxygenation level of critically ill patients prior to Rapid Sequence Intubation, which is an emergency airway management procedure.
Recent studies have highlighted that clinicians don’t properly oxygenate their patients prior to intubation, which, can lead to low oxygen levels, low blood pressure and in some case even cardiac arrest.
ETOM will allow paramedics and doctors to determine when it is safe to intubate their patients whilst also reducing the level of stress associated with this high-risk procedure.


Institution: Monash University

ANZCA PCORE: Pilot is a pilot national registry that will collect a minimum dataset on adults undergoing inpatient noncardiac surgery in Australia. Funded by an ANZCA Pilot Grant and developed in consultation with the Australian Commission for Safety and Quality in Health Care (ACSQHC), ANZCA PCORE: Pilot has ethics approval for a period of three years. There are 28 hospitals across Australia currently in the process of joining the pilot registry, representing every state and territory. In partnership with the CSIRO's Data 61 data science team, the registry will provide regular feedback to hospitals for quality assurance and research.


Institution: The University of Adelaide

The Hex20 hardware platform is based on flight proven, highly scalable and flexible spacecraft bus which will integrate raw computing power with highly complex algorithms for greater attitude control and image processing, which can deploy a real-time neural network for data driven control applications. The platform will be driven by data processing capability, with optional plug-and-play functional subsystems. A software library based on easily configurable architecture will allow customers to re-configure their platforms for new applications with less integration effort; enabling prioritisation of data enabled experiments. This modular and highly scalable architecture will lead to enormous cost savings.


Institution: The University of Adelaide

VitiCanopy is an accurate and inexpensive alternative to the current techniques used to measure and map vine canopy size and vineyard variability. Grape growers can obtain objective data with a simple snapshot instead of relying on expensive instrumentation or time-consuming destructive techniques. Smartphones also allow for the acquisition of geo-referenced data, which is then used to map the variation of canopy size in the vineyard and to identify zones of high or low biomass or water demand. The insights from this data can then inform management strategies to reach desired yield and fruit quality targets.

Endocytosis Therapeutics

Institution:  The University of Sydney

Immuno-oncology is a rapidly expanding field of cancer therapeutics, using highly specific antibodies to target cell-surface receptors. The average therapy response rate sits around 20–30%, leaving numerous patients with limited alternative options for treatment and survival. Cancer cells in non-responding patients internalise receptors inside the cell, hiding it from the antibody therapy, in a process known as endocytosis. Conversely, for patients that respond to treatment, receptors are routinely localised on the cell surface. Temporary inhibition of dynamin and endocytosis presents an opportunity to dramatically improve efficacy of immunotherapies, by preventing the route with which cancer cells evade antibodies.

3D Beam-Shaping Lens Antenna

Institution: University of Technology Sydney

The aim of this project is to develop new millimetre-wave beam-shaping techniques using metamaterial-inspired technologies. As an emerging field, the millimetre-wave frequency band has attracted tremendous attention for a wide range of applications, particularly, the telecommunication industry. This project proposes a novel scheme as a revolutionary resolution of millimetre-wave beamforming and shaping, which has significant meaning in beam control by restructuring the fundamental components, such as lenses and reflectors. Successful delivery of the project will testify the conceptual prototype resulting in a competitive idea for winning prestigious grants in the near future.

Soil Remediation

Institution: University of Technology Sydney

An enhanced electrokinetic (EK) process is suggested for the treatment and removal of organic pollutants and heavy metals from fined-grained soils. A porous and high-permeability permeable reactive barrier (PRB) will be strategically positioned in the soil for controlling the advancement of acid and alkaline fronts and capturing pollutants in the soil. The PRB medium will be either an organic or composite of an organic-inorganic matter of surface functional groups to capture solubilised contaminants in the soil. At the end of the EK process, contaminants are retrieved from the PRB by a suitable solvent for regeneration and reuse.


Institution: University of Technology Sydney

MemBrains project aims to develop an innovative biodegradable mulch film for the sustainable production of agricultural commodities in Australia. This mulch is not only capable of improving the agricultural productivity via increased soil temperature, suppressing weeds, conserving soil moisture, reducing pest insects and improving soil fertility, but also significantly reduces environmental pollution problems due to its ready biodegradation.

Sydnicon RF

Institution: University of Technology Sydney

Batteries don’t currently last the life of a sensor, leaving system designers with two options: either let the battery determine the life of sensors or create a strategy for replacing sensor batteries.
Sydnicon RF’s MMIC solution will allow wireless systems to transmit useful amounts of data while using as much  as it takes to push a button. There is huge market potential for this solution, as societies move towards more WSN Devices for a range of IoT applications from Smart Cities to Smart Agriculture.

Access Breeding

Institution: CSIRO Agriculture & Food

CSIRO has assembled a customisable, multi-component advanced technology breeding platform suitable for a range of crops. It includes the delivery of components in cost-effective, high-throughput technologies such as genomic selection, gene editing and phenotyping techniques (as examples) and their integration through support in crop specific expertise in physiology, breeding, genetics, pathology and agronomy. These are being made accessible to mid-level breeding programs to learn, adopt and access exemplar tools, techniques and capabilities. It’s anticipated that Access Breeding will fulfill a market need for mid-tier international breeding programs, allowing them to make step changes toward increased genetic gain and competitiveness.

SkullPro2 Smart Helmet

Institution: CSIRO's Data61

Brain swelling may ensue following brain injury and, in some cases, requires an operation to remove a section of the skull to alleviate intracranial pressure which can take months to subside. The project will implement a wearable smart skullcap with an integrated data processing framework for craniectomy patients. The proposed telehealth system will provide clinicians with personalised data driven assessments, using a near real time dashboard, facilitating rehabilitation and cranioplastic reconstruction leading to improved health outcomes for patients. Currently there is no device available that remotely monitors ‘brain swelling ‘and recovery in craniectomy patients making this approach entirely novel.


Institution: Australian National University

Team e3DP’s developed 3D printing method combines unprecedented three-dimensional control and material flexibility, to culminate in a new process for 2D patterning and 3D printing of polymeric, organic, semiconducting, or metallic materials into complex shapes. This 3D printer is expanding the range of materials that can be printed using a single device reducing the number of pre- and post-processing steps that are necessary to manufacture computer chips, implants, sensors, and other devices. This new technology offers a unique self-monitoring and self-learning advantage, which allows for on-the-fly quality control and adjustment of the printing process, while being environmentally friendly.

Leave it

Institution: Griffith University

The Leave It project delivers engaging programs designed with pet owners and supported by stakeholders. The program and approach has been proven to successfully engage pet owners and stakeholders to undertake behaviours that protect Australian wildlife. This program is for pet owners and local government areas and it features online training modules, marketing communication campaigns, community events and delivery of accreditation programs that can be delivered online or in-person.

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