We are looking for individuals 40+ years, who have knee pain that may be due to osteoarthritis to participate in a study investigating the benefits of krill oil supplementation on symptoms of osteoarthritis of the knee.


Osteoarthritis (OA) is a leading cause of chronic pain and disability world-wide and has been deemed a National Health Priority due to its significant impact on individual functioning and health service expenditure. Knee OA is common in older adults. Cartilage in the knee gradually wears away resulting in the bones of joints rub against each other causing pain, swelling, stiffness and reduced ability to move.

There is no cure for OA; treatments are aimed at improving symptoms and primarily includes painkillers (analgesics) and non-steroidal anti-inflammatory drugs (NSAIDs). Due to adverse effects associated with NSAID, a need exists for alternate therapies that safely and effectively reduce pain and inflammation and improve function in people with knee OA.

Krill oil, a rich source of omega-3 fatty acids and anti-oxidants, has been shown to have anti-inflammatory properties.

About this study

The aim of this study is to investigate the effectiveness of a high strength deep sea krill oil supplementation to reduce pain in adults with OA of the knee compared to a placebo over a six-month intervention period. Participants will be required to attend one of the following sites to complete questionnaires and have blood samples taken:

  • Adelaide: The CSIRO Nutrition and Health Research Clinic at SAHMRI, North Terrace Adelaide.
  • Melbourne: Emeritus Research in Melbourne, Victoria.
  • Sunshine Coast: The University of Sunshine Coast, Clinical Trials Centre, Queensland.

On completion of the study, participants will receive a Coles/Myer gift card valued at $445 to acknowledge their valuable contribution to scientific research.

Study criteria

You will need to meet the following key criteria to participate in this study:

  • are 40-65 years of age
  • have pain in one or both knees due to osteoarthritis
  • consume low levels omega-3 fatty acids from seafood or fish oil and willing to maintain low intakes
  • not allergic to seafood or shell fish
  • be able to attend four appointments over a seven month period at the clinic in your location.

If you have any queries about the Krill Oil and Knee Osteoarthritis Study or would like further information please call +61 8 8305 0615 or email CRUstudies@csiro.au

This study has been approved by the CSIRO Health and Medical Research Human Research Ethics Committee.

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