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Register your interest

If you would like to take part, please complete the online study registration form selecting “Cognitive Decline Study” from the drop-down menu. Further information about the study and key eligibility criteria can be found below.


Like many countries, Australia has an ageing population in which cognitive decline is a growing issue. There is an emerging body of research to suggest that consuming mushrooms may be associated with good brain health. This is because it contains components like Ergothioneine, which is thought to act as an antioxidant and anti-inflammatory compound.

Studies have already shown that Ergothioneine decreases with ageing and in people with impaired cognitive function. Research has also linked higher intake of mushrooms with a lower rate of dementia.

This study is being funded by a commercial sponsor, Phyto Tech Corp (trading as Blue California).

About this study

This study will be looking at the benefit of daily consumption of Ergothioneine in people who report memory complaints and will observe any benefit in cognition in these individuals.  In addition to the cognitive benefits, we will also measure sleep quality, mood and changes in biochemical (blood) markers.

Study criteria

We are looking for volunteers who have noticed changes in their memory skills and cognitive function.

For example, you may feel you have become more forgetful (such as often misplacing your keys, forgetting the details from a previous conversation etc), and have noticed difficulties with remembering things (for example appointments or lunch dates with friends), or find that doing tasks that you need to really focus and concentrate on is more difficult.

You will need to meet the following criteria to participate in this study:

  • Male or female aged 55 to 79 years
  • BMI between 18.5 and 35 (Inclusive. We can calculate this for you)
  • Have noticed some changes in your memory function
  • Not allergic to: Mushrooms, Microcrystalline cellulose, magnesium stearate, or silicon dioxide
  • Willing to attend a screening appointment and 3 visits in our clinic at SAHMRI over a 16-week period

*Note that other criteria exist and will be assessed during study screening

More information about the study can be found in the Participant Information Sheet PDF (235 KB)

Participate in this study

If you have any queries about this study or would like further information about participating do not hesitate to contact us, either by phone please call (08) 8305 0615 or email and we can assist.

If you feel you fit the criteria and would like to take part, please complete the online study registration form selecting “Cognitive Decline Study” from the drop-down menu.

This study has been approved by the CSIRO Health and Medical Research Human Research Ethics Committee. If you would like to speak with someone with respect to ethical matters or wish to register a formal complaint about the conduct of this research, please contact the Secretary of the Committee via email at or phone on (07) 3833 5693.

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