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The CSIRO BioFoundry offers services in the field of synthetic biology which applies engineering principles to biology. Synthetic biology makes it possible to develop more sustainable and effective solutions to tackle environmental, health, manufacturing and other industry challenges through designing and building biological systems.

Synthetic biology applications can include medical treatments like insulin that are produced without needing animal parts, biodegradable plastics made without petroleum products and microorganisms harnessed for bioremediation to clean pollutants from our water, soil and air.

How we work

The CSIRO BioFoundry operates in the Synthetic Biology Design - Build – Test – Learn bioengineering cycle.

Specialising in high-volume design and build services, the BioFoundry’s equipment allows us to perform full workflows,including combinatorial genetic design and high-throughput genetic strain build. This is made possible by our suite of robotics for DNA assembly and transformation. Our testing capacity extends to basic phenotyping and we can link in access to metabolomics, protein production, and other facilities in CSIRO.

Infographic explaining the CSIRO BioFoundry Design - Build - Test - Learn bioengineering cycle.

CSIRO BioFoundry Modular Workflows

Design

  • DNA design
  • DNA parts order

Build

  • DNA Assembly
  • Organism transformation
  • Colony pick

Test

  • Strain analysis
  • DNA recovery and analysis
  • Sequencing (outsourced)

Learn

  • Data analysis
  • AI/ML (Data61)
Choose the services that suit your project from our modular pipeline.

Recent projects include high-throughput multi-level combinatorial DNA construct assembly, ribosome binding site optimisation using machine learning and artificial intelligence, and cell-free protein expression.

Specialist equipment

The CSIRO BioFoundry offers a full suite of specialist equipment to meet the needs of projects in synthetic biology including:

  • Echo 525 liquid handler for nanoliter scale liquid transfer
  • Singer Pixl colony picking robot
  • Cybio Felix liquid hander
  • SciClone G3 liquid handler
  • ZAG DNA Analyzer
  • Cytoflex S flow cytometer
  • Cytoflex SRT cell sorter
  • Climatron photosynthetic organism growth cabinet.

Use this facility

CSIRO’s BioFoundry is based at the Ecosciences Precinct at Dutton Park and we are open for business. We welcome academia and industry, Australian and international clients. If you have an enquiry relating to the BioFoundry, please contact Dr Janet Reid.

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